Maarten Laroy, PhD
Scientific Articles
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First-author articles
Laroy, M., Emsell, L., Vandenbulcke, M., Bouckaert, F. (2025). Mapping electroconvulsive therapy induced neuroplasticity: Towards a multilevel understanding of the available clinical literature - A scoping review. Neurosci Biobehav Rev, 11:106143 (online ahead of print) doi: 10.1016/j.neubiorev.2025.106143
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Laroy, M., Van Laere, K., Vandenbulcke, M., Emsell, L. Bouckaert. F. (2024). Molecular positron emission tomography and single-photon emission computed tomography imaging for understanding the neurobiological mechanisms of electroconvulsive therapy: A scoping review. Journal of ECT, ():10.1097/YCT.0000000000001094. doi: 10.1097/YCT.0000000000001094
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Laroy, M., Bouckaert, F., Ousdal, OT., Dols, A., Rhebergen, D., ..., Oltedal, L, Emsell, L. for GEMRIC. (2024). Characterization of gray matter volume changes from one week to 6 months after termination of electroconvulsive therapy in depressed patients. BRAIN STIMULATION, 17(4):876-886. doi: 10.1016/j.brs.2024.07.015
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Laroy, M, Vande Casteele, T., Van Cauwenberge, M., Koole, M., Dupont, P., Sunaert, S., Van den Stock, J., Sienaert, P., Van Laere, K., Vandenbulcke, M., Emsell, L., Bouckaert, F. (2024). Synaptic density changes following electroconvulsive therapy: A longitudinal pilot study with PET-MR 11C-UCB-J imaging in late-life depression. BRAIN STIMULATION, 17(3):588-590. doi: 10.1016/j.brs.2024.04.020
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Laroy, M., Vansteelandt, K., Emsell, L., Van den Stock, J., Vandenbulcke, M., Bouckaert, F. (2021). Response to Volume Increase in the Dentate Gyrus Induced by Electroconvulsive Therapy Shedding Light on the Clinical Relevance of Plasticity in the Hippocampus. JOURNAL OF ECT, 37 (1), doi: 10.1097/YCT.0000000000000715.
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Laroy, M., Weydts, J., Vansteelandt, K., Emsell, L., Adamson, C., Sienaert, P., Dols, A., Rhebergen, D., Stek, M., Vandenbulcke, M., Bouckaert, F. (2019). Cortisol is not associated with pre-treatment medial temporal lobe volume or volume changes after electroconvulsive therapy in patients with late-life depression. PSYCHIATRY RESEARCH-NEUROIMAGING, 291, 26-33. doi: 10.1016/j.pscychresns.2019.07.006
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Laroy, M., Bouckaert, F., Vansteelandt, K., Obbels, J., Dols, A., Emsell, L., Stek, M., Vandenbulcke, M., Sienaert, P. (2019). Association between hippocampal volume change and change in memory following electroconvulsive therapy in late-life depression. ACTA PSYCHIATRICA SCANDINAVICA, 140 (5), 435-445. doi: 10.1111/acps.13086
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Co-author articles
2025
Takamiya, A., Vande Casteele, T., Bouckaert, F., Van Cauwenberge, MG., Laroy, M., De Winter, FL., ..., Vandenbulcke, M. (2025). Accelerated aging of white matter in late-life depression: evidence from 18F-flutemetamok PET imaging. Biol Psychiatry Cogn Neurosci Neuroimaging, 7:S2451-9022(25)00126-0. doi: 10.1016/j.bpsc.2025.03.013
Van Cauwenberge, MGA., Vande Casteele, T., Laroy, M., Vansteelandt, K., Van den Stock, J., Bouckaert, F., Emsell, L., Vandenbulcke, M. (2025). Motor dysfunction in late life depression: A mood or movement disorder? J Affect Disord., 7:S0165-0327(25)00613-5. doi: 10.1016/j.jad.2025.04.053
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Lien, CH., Vande Casteele, T., Laroy, M., Van Cauwenberge, M., Peeters, R., ..., Van den Stock, J. (2025). Are resting-state network alterations in late-life depression related to synaptic density? Findings from a combined 11C-UCB-J PET and fMRI study. Cereb Cortex, 6;35(3):bhaf028. doi: 10.1093/cercor/bhaf028
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Sun, J., De Vocht, J., Stam, D., Lien, C-H., ... Laroy, M., ... Van den Stock, J. (2025). Neural correlates of memory deficits in premanifest C9orf72-repeat expansions. J Neurol Neurosurg Psychiatry, jnnp-2024-335169. doi: 10.1136/jnnp-2024-335169
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Takamiya, A., Radwan, A., Christiaens, D., Van Cauwenberge, M., Vande Casteele, T., Laroy, M., Vansteelandt, K., Sunaert, S., Koole, M., Van den Stock, J., Van Laere, K., Bouckaert, F., Vandenbulcke, M., Emsell. L. (2025). Gray and white matter differences in the medial temporal lobe in late-life depression: a multimodal PET-MRI investigation. Psychol Med., 4:55:e10. doi: 10.1017/S0033291724003362
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2024
Kiebs, M., Farrar, D., Yrondi, A., Cardoner, N., Tuovinen, N., Redlich, R., .. Laroy, M., .., Abbott, C. (2024). Electroconvulsive therapy and cognitive performance from the Global ECT MRI Research Collaboration. Journal of Psychiatric Research, 179:199-208. doi: 10.1016/j.jpsychires.2024.09.013
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Vande Casteele, T., Laroy, M., Van Cauwenberge, MGA., Vanderlinden, G., Vansteelandt, K., Koole, M., Dupont, P., Van Den Bossche, M., Van den Stock, J., Bouckaert, F., Van Laere, K., Emsell, L., Vandenbulcke, M. (2024). Late Life Depression is Not Associated with Alzheimer-Type Tau: Preliminary Evidence froma Next-Generation Tau Ligand PET-MR Study. Am J Geriatr Psychiatry, 24, 401-9. doi: 10.1016/j.jagp.2024.07.005
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Vande Casteele, T., Laroy, M., Van Cauwenberge, M., Koole, M., Dupont, P., Sunaert, S., Van den Stock, J., Bouckaert, F., Van Laere, K., Emsell, L., Vandenbulcke, M. (2024). Preliminary evidence for preserved synaptic density in late-life depression. Transl Psychiatry, 14 (1). doi: 10.1038/s41398-024-02837-8
2023
Feenstra, T.C., Cruz, E.K J L., Obbels, J., Laroy, M., Bouckaert, F., Sienaert, P., Oudega, M., Dols, A., Exel, E.V., Beekman, A.T F., Rhebergen, D. (2023). The Cortisol Awakening Response as a Biomarker for Cognitive Side-Effects of Electroconvulsive Therapy. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 31 (11), 991-995. doi: 10.1016/j.jagp.2023.07.004
Van Cauwenberge, M.G A., Delva, A., Vande Casteele, T., Laroy, M., Radwan, A., Vansteelandt, K., Van den Stock, J., Bouckaert, F., Van Laere, K., Emsell, L., Vandenberghe, W., Vandenbulcke, M. (2023). Mild Motor Signs in Healthy Aging Are Associated with Lower Synaptic Density in the Brain. MOVEMENT DISORDERS, 38 (10), 1786-1794. doi: 10.1002/mds.29570
2021
De Vocht, J., Stam, D., Nicolini, M., Lamaire, N., Laroy, M., Vande Casteele, T., van de Vliet, L., Vansteelandt, K., D'Hondt, A., Emsell, L., Bruffaerts, R., Vandenbulcke, M., van Damme, P., van den Stock, J. (2021). Psychopathology in premanifest C9orf72 repeat expansion carriers. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 93 (5), 565-567. doi: 10.1136/jnnp-2021-327774
Takamiya, A., Bouckaert, F., Laroy, M., Blommaert, J., Radwan, A., Khatoun, A., Deng, Z-D., Mc Laughlin, M., Van Paesschen, W., De Winter, F-L., Van den Stock, J., Sunaert, S., Sienaert, P., Vandenbulcke, M., Emsell, L. with Vandenbulcke, M. (corresp. author), Emsell, L. (corresp. author) (2021). Biophysical mechanisms of electroconvulsive therapy-induced volume expansion in the medial temporal lobe: A longitudinal in vivo human imaging study. BRAIN STIMULATION, 14 (4), 1038-1047. doi: 10.1016/j.brs.2021.06.011
Emsell, L., Laroy, M., Van Cauwenberge, M., Vande Casteele, T., Vansteelandt, K., Van Laere, K., Sunaert, S., Van den Stock, J., Bouckaert, F., Vandenbulcke, M. (2021). The Leuven late life depression (L3D) study: PET-MRI biomarkers of pathological brain ageing in late-life depression: study protocol. BMC PSYCHIATRY, 21 (1), Art.No. ARTN 64. doi: 10.1186/s12888-021-03063-y
Preprints
Laroy, M., Saito, T., Saido, R., D'Hooge, R., Van der Jeugd, A. (2019). Isolation housing exacerbates Alzheimer’s Disease phenotype in aged APP KI mice. bioRxiv. doi: https://doi.org/10.1101/777524
Doctoral Thesis
Laroy, M. (2024).
Title: Multimodal imaging of neuroplasticity following electroconvulsive therapy for depression
Supervisors: Bouckaert, F., Emsell, L., Van den Stock, J., Vandenbulcke, M.
Dissertation presented in partial fulfilment of the requirements for the degree of Doctor in Biomedical Sciences at KU Leuven, Belgium